IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10597375 B1

PDFFull Text
Date of Patent:
Mar. 24, 2020

Filed:

May. 08, 2018

Halogen-substituted heterocyclic compound

Applicant:

Ube Industries, Ltd., Ube-shi, Yamaguchi, JP;

Inventors:

Noriaki Iwase, Ube, JP;

Hiroshi Nishida, Ube, JP;

Makoto Okudo, Ube, JP;

Masaaki Ito, Ube, JP;

Shigeyuki Kono, Ube, JP;

Masaaki Matoyama, Ube, JP;

Shigeru Ushiyama, Ube, JP;

Eiji Okanari, Ube, JP;

Hirofumi Matsunaga, Ube, JP;

Kenji Nishikawa, Ube, JP;

Tomio Kimura, Tokyo, JP;

Assignee:

UBE INDUSTRIES, LTD., Ube-shi, JP;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Patricia L Morris

Int. Cl.
CPC ...
A61K 31/381 (2006.01); C07D 333/36 (2006.01); A61K 31/427 (2006.01); A61K 31/443 (2006.01); C07D 409/04 (2006.01); C07D 409/14 (2006.01); C07D 417/12 (2006.01); A61P 43/00 (2006.01); A61P 25/00 (2006.01); A61P 37/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 13/00 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
C07D 333/36 (2013.01); A61K 31/381 (2013.01); A61K 31/427 (2013.01); A61K 31/443 (2013.01); A61P 13/00 (2018.01); A61P 25/00 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01); A61P 43/00 (2018.01); C07D 409/04 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01);
Abstract

A novel α-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided. A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; Ris the same or different, and represents a halogen atom, or a C-Calkyl group; Rrepresents a hydrogen atom, or a C-Calkyl group; p represents an integer of 0 to 5; V represents CRwherein Rrepresents a hydrogen atom, an amino group, a nitro group, or a C-Calkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.

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