The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2020
Filed:
May. 24, 2018
The Governing Council of the University of Toronto, Toronto, CA;
Bernhard Ganss, Toronto, CA;
Yuichi Ikeda, Tokyo, JP;
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, Toronto, ON, CA;
Abstract
This disclosure provides a product comprised of a collagen gel to which recombinant human Amelotin (AMTN) protein is added. This AMTN-collagen gel is applied to one side of a physiologically acceptable scaffold that has first been impregnated with AMTN-free collagen gel. The resulting two-layer collagen membrane (layer 1 comprised of scaffold surrounded by collagen gel; layer 2 comprised of collagen gel containing AMTN) is applied to a mineralized tissue surface such as dentin and bone with the collagen gel containing AMTN of layer 2 facing this mineral surface. Upon immersion in simulated body fluid (SBF), the presence of AMTN in layer 2 triggers the formation of hydroxyapatite mineral deposits that intimately connect with the existing mineral surface and thus provide physical attachment. A similar product is disclosed but in addition to AMTN, it contains the Odontogenic, Ameloblast-Associated (ODAM) protein as well with both proteins exhibiting a synergistic effect.