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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10596195 B1

PDFFull Text
Date of Patent:
Mar. 24, 2020

Filed:

Jan. 13, 2017

Discovery of regulatory t cells programmed to suppress an immune response

Applicant:

Dana-farber Cancer Institute, Inc., Boston, MA (US);

Inventors:

Harvey Cantor, Boston, MA (US);

Hye-Jung Kim, Brookline, MA (US);

Linrong Lu, Hangzhou, CN;

Assignee:

Dana-Farber Cancer Institute, Inc., Boston, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Michail A Belyavskyi

Int. Cl.
CPC ...
A61K 35/26 (2015.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); C12N 5/0783 (2010.01); A61K 9/00 (2006.01); A61K 38/20 (2006.01); C07K 16/24 (2006.01); C07K 16/28 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 9/0019 (2013.01); A61K 38/2086 (2013.01); A61K 39/0008 (2013.01); A61K 39/0011 (2013.01); C07K 16/244 (2013.01); C07K 16/2803 (2013.01); C12N 5/0637 (2013.01); A61K 2035/122 (2013.01); A61K 2035/124 (2013.01); A61K 2039/5152 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/55522 (2013.01); C07K 2317/31 (2013.01); C07K 2317/75 (2013.01); C12N 2501/2315 (2013.01); C12N 2501/2321 (2013.01); C12N 2502/1114 (2013.01);
Abstract

A method to treat an autoimmune disease is provided. The method involves administration of interleukin-15 receptor (IL-15R) agonists in an amount effective to ameliorate a symptom of the autoimmune disease. The invention also involves a method to treat an autoimmune disease by ex-vivo expansion of CD44+CD122+Kir+ CD8+ Treg cells and administration of the CD44+CD122+Kir+ CD8+ Treg cells. Compositions comprising CD44+CD122+Kir+ CD8+ Treg cells are also provided. Methods for stimulating an immune response to an antigen are also provided.

Find Patent Forward Citations

Cantor, Harvey. (2020). Discovery of regulatory t cells programmed to suppress an immune response (U.S. Patent No. 10596195). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10596195

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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