The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 24, 2020

Filed:

Aug. 29, 2018
Applicant:

Novartis Ag, Basel, CH;

Inventors:

Agnes Biggart, Spring Valley, CA (US);

Fang Liang, Encinitas, CA (US);

Casey Jacob Nelson Mathison, San Diego, CA (US);

Valentina Molteni, San Diego, CA (US);

Advait Suresh Nagle, San Diego, CA (US);

Frantisek Supek, San Diego, CA (US);

Vince Yeh, San Diego, CA (US);

Assignee:

Novartis AG, Basel, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); C07D 519/00 (2006.01); C07F 5/02 (2006.01); C07F 7/08 (2006.01); A61K 31/5377 (2006.01); A61K 31/695 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/695 (2013.01); A61K 45/06 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01); C07F 5/027 (2013.01); C07F 7/0814 (2013.01); Y02A 50/409 (2018.01); Y02A 50/414 (2018.01); Y02A 50/415 (2018.01);
Abstract

The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.


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