The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 24, 2020
Filed:
Aug. 24, 2016
Sven Erik Godtfredsen, Chatham, NJ (US);
Dion Hubert Zappe, Andover, NJ (US);
Weinong Guo, Bridgewater, NJ (US);
Jack Ziyu Zhang, Fortworth, TX (US);
Sven Erik Godtfredsen, Chatham, NJ (US);
Dion Hubert Zappe, Andover, NJ (US);
Weinong Guo, Bridgewater, NJ (US);
Jack Ziyu Zhang, Fortworth, TX (US);
Novartis AG, Basel, CH;
Abstract
The present invention relates to methods and pharmaceutical compositions for reducing arterial stiffness in a human patient showing at least one symptom selected from increased pulse wave velocity (PWV) and increased pulse pressure (PP) comprising administration to said patient of a therapeutically effective amount or a prophylactically effective amount of a combination of a therapeutic agent blocking the angiotensin receptor and a therapeutic agent inhibiting the NEP enzyme, in particular of a combination of sacubitril or a pharmaceutically acceptable salt thereof and valsartan or a pharmaceutically acceptable salt thereof in a 1:1 molar ratio.