The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Apr. 27, 2016
University of Maryland, College Park, College Park, MD (US);
Children's National Medical Center, Washington, DC (US);
Omar Bilal Ayyub, Potomac, MD (US);
Adam Michael Behrens, Olney, MD (US);
Peter Kofinas, North Bethesda, MD (US);
Marshall Lynn Summar, II, Washington, DC (US);
Juan Manuel Cabrera-Luque, Rockville, MD (US);
Gary Cunningham, Washington, DC (US);
University of Maryland, College Park, College Park, MD (US);
Children's National Medical Center, Washington, DC (US);
Abstract
The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.