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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10591445 B1

PDFFull Text
Date of Patent:
Mar. 17, 2020

Filed:

Nov. 22, 2016

Methods for analysis and resolution of preparations of dianhydrogalactitol and derivatives or analogs thereof

Applicant:

Del Mar Pharmaceuticals (Bc) Ltd., Vancouver, CA;

Inventor:

Qiang Xu, Menlo Park, CA (US);

Assignee:

Del Mar Pharmaceuticals (BC) Ltd., Vancouver, CA;

Attorney:

Christensen O'Connor Johnson Kindness PLLC

Primary Examiner:

Xiaoyun R Xu

Int. Cl.
CPC ...
G01N 30/22 (2006.01); C07D 303/14 (2006.01); G01N 30/74 (2006.01); G01N 30/88 (2006.01); G01N 30/30 (2006.01); G01N 30/72 (2006.01); G01N 30/02 (2006.01); G01N 30/32 (2006.01); B01D 15/30 (2006.01); G01N 30/34 (2006.01);
U.S. Cl.
CPC ...
G01N 30/22 (2013.01); C07D 303/14 (2013.01); G01N 30/74 (2013.01); G01N 30/88 (2013.01); B01D 15/305 (2013.01); G01N 30/30 (2013.01); G01N 30/34 (2013.01); G01N 30/7233 (2013.01); G01N 2030/027 (2013.01); G01N 2030/324 (2013.01); G01N 2030/8872 (2013.01);
Abstract

An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (HPLC), in particular, HPLC employing a reverse phase amide column with ELSD detection; the HPLC can be followed by tandem mass spectroscopy. The method can further comprise the step of performing preparative HPLC collection of at least one specific substance peak present in a preparation of dianhydrogalactitol.

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