The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 2020

Filed:

Dec. 11, 2017
Applicants:

The Curators of the University of Missouri, Columbia, MO (US);

Clemson University, Clemson, SC (US);

Inventors:

Yinfa Ma, Rolla, MO (US);

Honglan Shi, Rolla, MO (US);

Qingbo Yang, Rolla, MO (US);

Hai Xiao, Clemson, SC (US);

Assignees:

The Curators of the University of Missouri, Columbia, MO (US);

Clemson University, Clemson, SC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/77 (2006.01); G01N 21/64 (2006.01); G01N 31/22 (2006.01); G01N 21/76 (2006.01); G01N 21/80 (2006.01);
U.S. Cl.
CPC ...
G01N 21/7703 (2013.01); G01N 21/645 (2013.01); G01N 21/6428 (2013.01); G01N 21/76 (2013.01); G01N 21/80 (2013.01); G01N 31/221 (2013.01); G01N 2021/6434 (2013.01); G01N 2021/772 (2013.01); G01N 2021/7786 (2013.01); G01N 2201/0636 (2013.01); G01N 2201/08 (2013.01);
Abstract

A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned on the tip of the micro-probe. The light signal excites the luminescent material so that the luminescent material emits a luminescent light signal. The luminescent light signal has a property value dependent on the pH or temperature being measured and reflects back through the shaft for being measured by a light signal measuring device. The immuno-based micro-probe includes a reflective material that has an effective refractive index dependent on the number of antigen-antibody bonds present on the reflective material.


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