IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10590395 B1

PDFFull Text
Date of Patent:
Mar. 17, 2020

Filed:

May. 22, 2015

Mutein, method for producing said mutein, gene encoding said mutein, recombinant vector and plant bearing said gene, method for controlling amount of mevalonic acid produced and amount of isoprenoid produced, method for controlling 3-hydroxy-3-methylglutaryl-coa reductase activity

Applicants:

Osaka University, Suita-shi, Osaka, JP;

Sumitomo Rubber Industries, Ltd., Kobe-shi, Hyogo, JP;

Inventors:

Keiko Suzuki, Suita, JP;

Jekson Robertlee, Suita, JP;

Toshiya Muranaka, Suita, JP;

Keiji Takagi, Kobe, JP;

Yukino Inoue, Kobe, JP;

Kazuhisa Fushihara, Kobe, JP;

Assignees:

OSAKA UNIVERSITY, Osaka, JP;

SUMITOMO RUBBER INDUSTRIES, LTD., Kobe-Shi, Hyogo, JP;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Weihua Fan

Int. Cl.
CPC ...
C12N 15/82 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 9/04 (2006.01); A01H 5/00 (2018.01); A01N 37/18 (2006.01); C12P 5/02 (2006.01); C12P 7/40 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0006 (2013.01); A01H 5/00 (2013.01); A01N 37/18 (2013.01); C12N 15/00 (2013.01); C12N 15/09 (2013.01); C12N 15/8243 (2013.01); C12Y 101/01034 (2013.01); C12P 5/02 (2013.01); C12P 7/40 (2013.01);
Abstract

Provided is a mutant protein obtained by mutating a specific amino acid residue of HMGR, a rate-limiting enzyme of isoprene monomer biosynthesis in the polyisoprenoid biosynthesis pathway. The present invention relates to a mutant protein, wherein at least one amino acid residue selected from the group consisting of amino acid residues at positions 91, 225, 257, 287, 339, 411, 470, 509 and 574 of the3-hydroxy-3-methylglutaryl CoA reductase shown by SEQ ID NO:1 and amino acid residues at positions corresponding to the foregoing in 3-hydroxy-3-methylglutaryl CoA reductase is deleted or replaced with another amino acid residue.

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