The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 2020

Filed:

Nov. 13, 2009
Applicants:

Anthony Atala, Winston-Salem, NC (US);

James J. Yoo, Winston-Salem, NC (US);

Inventors:

Anthony Atala, Winston-Salem, NC (US);

James J. Yoo, Winston-Salem, NC (US);

Assignee:

WAKE FOREST UNIVERSITY HEALTH SCIENCES, Winston-Salem, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/22 (2015.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0686 (2013.01); A61K 35/22 (2013.01); A61K 35/12 (2013.01); C12N 2500/02 (2013.01);
Abstract

Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein the cells have been expanded in vitro. The kidney cells preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells express EPO in vivo in an oxygen tension-dependent manner.


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