The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Aug. 16, 2017
Applicant:
Fujifilm Cellular Dynamics, Inc., Madison, WI (US);
Inventors:
Christopher W. McMahon, Madison, WI (US);
Lauren E. Little, Madison, WI (US);
Wen Bo Wang, Madison, WI (US);
Nathaniel A. Elliott, Madison, WI (US);
Assignee:
FUJIFILM Cellular Dynamics, Inc., Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/0793 (2010.01); A61K 38/18 (2006.01); C12N 5/0797 (2010.01); C07C 215/28 (2006.01); C07C 229/36 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0619 (2013.01); A61K 38/185 (2013.01); C12N 5/0623 (2013.01); C07C 215/28 (2013.01); C07C 229/36 (2013.01); C12N 2501/415 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); G01N 33/5058 (2013.01); G01N 33/5073 (2013.01);
Abstract
Methods are provided, in some aspects, for differentiating pluripotent cells into midbrain dopaminergic (DA) neurons using a mono-SMAD inhibition or inhibition of SMAD signaling with only one SMAD inhibitor. In some embodiments, mono-SMAD inhibition utilizes a single inhibitor of bone morphogenic protein (BMP) for differentiating pluripotent cells into midbrain DA neurons.