The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Sep. 10, 2019
King Saud University, Riyadh, SA;
Abdulrahman Ibrahim Almansour, Riyadh, SA;
Suresh Kumar Raju, Riyadh, SA;
Arumugam Natarajan, Riyadh, SA;
Rajapandiyan Krishnamoorthy, Riyadh, SA;
Ali A. Alshatwi, Riyadh, SA;
King Saud University, Riyadh, SA;
Abstract
The spirooxindole-pyrrolothiazole heterocyclic hybrids are compounds having the formula: wherein R is hydrogen and R' is fluorine (compound 6a) or R is fluorine and R′ is hydrogen (compound 6b). The hybrids may be obtained using a chemical synthesis process involving 1,3-dipolar cycloaddition of 3,5-bis(4/2-fluoro-benzylidene) piperidin-4-ones with isatin and 4-thiazolidinecarboxylic acid in a suitable solvent, preferably 1-butyl-3-methyl-imidazolium bromide ('[bmim]Br'), and preferably under microwave irradiation. Both of these new hybrids demonstrate antimicrobial activity against both gram positive and gram negative drug resistant and non-resistant bacterial pathogens, although compound 6a exhibits more potent antibacterial activity than compound 6b.