The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Jul. 14, 2017
Applicant:
Italfarmaco Spa, Milan, IT;
Inventors:
Andrea Stevenazzi, Milan, IT;
Giovanni Sandrone, Novara, IT;
Daniela Modena, Monza, IT;
Samuele Pietro Pozzi, Legnano, IT;
Barbara Vergani, Macherio, IT;
Maria Lattanzio, Milan, IT;
Paolo Mascagni, Alicante, ES;
Christian Steinkühler, Rome, IT;
Gianluca Fossati, Milan, IT;
Assignee:
ITALFARMACO SPA, Milan, IT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 317/60 (2006.01); C07D 215/14 (2006.01); C07D 407/12 (2006.01); C07D 213/643 (2006.01); C07D 209/18 (2006.01); A61P 35/00 (2006.01); C07C 259/10 (2006.01); C07D 213/56 (2006.01); C07D 221/04 (2006.01); C07D 233/64 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 417/12 (2006.01); A61K 31/165 (2006.01); A61K 31/357 (2006.01); A61K 31/4035 (2006.01); A61K 31/443 (2006.01); A61K 31/47 (2006.01); C07D 317/06 (2006.01);
U.S. Cl.
CPC ...
C07D 317/60 (2013.01); A61P 35/00 (2018.01); C07C 259/10 (2013.01); C07D 209/18 (2013.01); C07D 213/56 (2013.01); C07D 213/643 (2013.01); C07D 215/14 (2013.01); C07D 221/04 (2013.01); C07D 233/64 (2013.01); C07D 405/12 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 417/12 (2013.01);
Abstract
The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts, isomers and prodrugs thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.