The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Nov. 02, 2015
Iomet Pharma Ltd., Edinburgh, Midlothian, GB;
Phillip M. Cowley, Edinburgh, GB;
Alan Wise, Edinburgh, GB;
Susan Davis, Dundee, GB;
Michael Kiczun, Dundee, GB;
Other;
Abstract
Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises formula (I) wherein X, and Xmay be the same or different and each is independently selected from C, N, O and S; X, X, X, and Xmay be the same or different and each is independently selected from C and N; each bond represented by a dotted line may be present or absent, provided that at least one such bond is present; R, R, R, R, Rand Rmay be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of R, R, R, R, Rand Rgroups present is such that the respective valencies of X, X, X, X, X, and Xare maintained; and wherein at least one of Rand Rcomprises a group Y, wherein Y is a group having a formula selected from (II), (III), (IV), (V), (VI), (VII) wherein L may be present or absent, and may be a substituted or unsubstituted organic linking group; Rand Rmay be the same or different and are selected from H and a substituted or unsubstituted organic group; each Rmay be the same or different and is selected from H and a substituted or unsubstituted organic group; Ris selected from a substituted or unsubstituted alcohol group or ether group; each Rmay be the same or different and is selected from H and a substituted or unsubstituted organic group; Xmay be selected from C and N; X, X, X, X, X, X, X, Xand Xmay be the same or different and each is independently selected from C, N, O and S; each bond represented by a dotted line may be present or absent; and each Rmay be the same or different and is selected from H and a substituted or unsubstituted organic group.