logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10590084 B1

PDFFull Text
Expired
Date of Patent:
Mar. 17, 2020

Filed:

Mar. 08, 2017

Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof

Applicant:

Blade Therapeutics, Inc., South San Francisco, CA (US);

Inventors:

Brad Owen Buckman, Oakland, CA (US);

John Beamond Nicholas, Redwood City, CA (US);

Shendong Yuan, San Ramon, CA (US);

Marc Adler, Orinda, CA (US);

Assignee:

Blade Therapeutics, Inc., South San Francisco, CA (US);

Attorney:

Knobbe, Martens, Olson & Bear, LLP

Primary Examiner:

Golam M Shameem

Int. Cl.
CPC ...
C07D 223/12 (2006.01); C07D 225/02 (2006.01); C07D 211/58 (2006.01); C07K 5/062 (2006.01); A61P 19/04 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07D 223/12 (2013.01); A61P 19/04 (2018.01); C07D 211/58 (2013.01); C07D 225/02 (2013.01); C07K 5/06034 (2013.01); A61K 38/00 (2013.01);
Abstract

The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.

Find Patent Forward Citations

Buckman, Brad. (2020). Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof (U.S. Patent No. 10590084). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10590084

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…