The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Mar. 08, 2017
Applicant:
Blade Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Brad Owen Buckman, Oakland, CA (US);
John Beamond Nicholas, Redwood City, CA (US);
Shendong Yuan, San Ramon, CA (US);
Marc Adler, Orinda, CA (US);
Assignee:
Blade Therapeutics, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 223/12 (2006.01); C07D 225/02 (2006.01); C07D 211/58 (2006.01); C07K 5/062 (2006.01); A61P 19/04 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07D 223/12 (2013.01); A61P 19/04 (2018.01); C07D 211/58 (2013.01); C07D 225/02 (2013.01); C07K 5/06034 (2013.01); A61K 38/00 (2013.01);
Abstract
The present technology relates to cyclic keto-amide compounds of general formulae I to XXXII, compositions and kits thereof as calpain modulators and methods useful for the treatment of various diseases or disorders such as fibrotic disease or cancer which are associated or mediated, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is also applicable to cyclic keto-amide compounds which inhibit myofibroblast differentiation.