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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10590078 B1

PDFFull Text
Date of Patent:
Mar. 17, 2020

Filed:

Feb. 11, 2016

Sodium channel blockers

Applicant:

Daewoong Pharmaceutical Co., Ltd., Gyeonggi-do, KR;

Inventors:

Ji Duck Kim, Gyeonggi-do, KR;

Hyung Geun Lee, Gyeonggi-do, KR;

Inwoo Kim, Seoul, KR;

Sun Ah Jun, Gyeonggi-do, KR;

Myunggi Jung, Gyeonggi-do, KR;

Hyo Shin Kim, Incheon, KR;

Assignee:

Daewoong Pharmaceutical Co., Ltd., Gyeonggi-do, KR;

Attorney:

Marshall, Gerstein & Borun LLP

Primary Examiner:

Samantha L Shterengarts

Int. Cl.
CPC ...
A61K 31/437 (2006.01); A61K 31/416 (2006.01); A61K 31/4439 (2006.01); C07D 209/10 (2006.01); C07D 231/56 (2006.01); C07D 401/04 (2006.01); C07D 401/06 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 403/12 (2006.01); C07D 209/30 (2006.01); C07D 209/42 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 209/10 (2013.01); C07D 209/30 (2013.01); C07D 209/42 (2013.01); C07D 231/56 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and use thereof. The compound represented by the Formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof can be effectively used in the prevention or treatment of pains, for example, acute pain, chronic pain, pain from nervous disease, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, paroxysmal extreme pain disorder (PEPD).

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