The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
May. 09, 2017
Applicant:
Purdue Research Foundation, West Lafayette, IN (US);
Inventors:
Ruben Claudio Aguilar, West Lafayette, IN (US);
Timothy L. Ratliff, West Lafayette, IN (US);
Assignee:
Purdue Research Foundation/OTC, West Lafayette, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61K 38/16 (2006.01); C07K 14/34 (2006.01); C07K 14/32 (2006.01); C07K 14/485 (2006.01); A61K 47/64 (2017.01);
U.S. Cl.
CPC ...
A61K 38/1808 (2013.01); A61K 38/164 (2013.01); A61K 47/6415 (2017.08); C07K 14/32 (2013.01); C07K 14/34 (2013.01); C07K 14/485 (2013.01); C07K 2319/00 (2013.01); C07K 2319/55 (2013.01);
Abstract
Provided is a method of treating a bladder cancer in an animal or human comprising: administering to an animal or human patient a therapeutic composition comprising a first fusion protein capable of specifically binding to an epidermal growth factor receptor (EGFR) on the surface of a cancer cell and comprising an epidermal growth factor (EGF) polypeptide conjugated to a bacterial toxin polypeptide and a second fusion protein comprising an anthrax Lethal Factor N-terminus (LF) conjugated to a Diptheria Toxin A (DTA) catalytic domain.