The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2020
Filed:
Oct. 02, 2017
Applicant:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Inventors:
Amato J. Giaccia, Stanford, CA (US);
Mihalis S. Kariolis, Stanford, CA (US);
Todd A. Aguilera, Stanford, CA (US);
Assignee:
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); C07K 14/705 (2006.01); A61P 31/22 (2006.01); A61P 31/12 (2006.01); A61P 31/20 (2006.01); A61P 31/14 (2006.01); A61P 31/18 (2006.01); A61P 31/04 (2006.01); A61P 35/04 (2006.01); A61P 31/10 (2006.01); A61K 38/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1774 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01); A61P 31/10 (2018.01); A61P 31/12 (2018.01); A61P 31/14 (2018.01); A61P 31/18 (2018.01); A61P 31/20 (2018.01); A61P 31/22 (2018.01); A61P 35/04 (2018.01); C07K 14/70503 (2013.01); A61K 38/00 (2013.01);
Abstract
Provided herein are compositions and methods for alleviating cancer or infection in a subject by administering a therapeutically effective amount of a pharmaceutical composition comprising an isolated PD-1 variant polypeptide. The PD-1 variant polypeptide can inhibit the activity of PD-1 by, for example, competitive or non-competitive inhibition of the interaction between wild-type PD-1 and one or more of its ligands, PD-L1 and PD-L2.