The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 2020

Filed:

Jun. 03, 2016
Applicants:

Kura Oncology, Inc., San Diego, CA (US);

The Regents of the University of Michigan, Ann Arbor, MI (US);

Inventors:

Jolanta Grembecka, Ann Arbor, MI (US);

Tomasz Cierpicki, Ann Arbor, MI (US);

Dmitry Borkin, Ann Arbor, MI (US);

Jonathan Pollock, Ann Arbor, MI (US);

Liansheng Li, San Diego, CA (US);

Tao Wu, Carlsbad, CA (US);

Jun Feng, San Diego, CA (US);

Pingda Ren, San Diego, CA (US);

Yi Liu, San Diego, CA (US);

Assignees:

KURA ONCOLOGY, INC., San Diego, CA (US);

THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 401/14 (2006.01); A61K 31/519 (2006.01); A61P 35/02 (2006.01); A61P 3/10 (2006.01); A61K 31/5377 (2006.01); A61K 31/541 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/541 (2013.01); A61P 3/10 (2018.01); A61P 35/02 (2018.01);
Abstract

The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.


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