The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Apr. 28, 2016
Applicants:
Kyoto University, Kyoto-shi, Kyoto, JP;
Japanese Foundation for Cancer Research, Koto-ku, Tokyo, JP;
Inventors:
Assignees:
Kyoto University, Kyoto, JP;
Japanese Foundation for Cancer Research, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/574 (2006.01); A61K 39/395 (2006.01); C12Q 1/68 (2018.01); C12N 15/09 (2006.01); A61K 45/00 (2006.01); C07K 16/28 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57407 (2013.01); A61K 39/395 (2013.01); A61K 45/00 (2013.01); C07K 16/2827 (2013.01); C12N 15/09 (2013.01); C12Q 1/68 (2013.01); G01N 33/574 (2013.01); G01N 33/5743 (2013.01); G01N 33/57411 (2013.01); G01N 33/57423 (2013.01); G01N 33/57426 (2013.01); G01N 33/57446 (2013.01); C07K 16/18 (2013.01); G01N 2333/70521 (2013.01); G01N 2333/70532 (2013.01); G01N 2800/52 (2013.01);
Abstract
An object of the present invention is to provide an effective method of predicting an effect of treatment by a PD-1/PD-L1 blockade, which is a method of predicting whether or not PD-1/PD-L1 blockade is effective for treatment of a subject suffering from a malignant tumor, which comprises detecting abnormality of genome relating to effectiveness of the PD-1/PD-L1 blockade in a tumor cell taken from the subject and evaluating the PD-1/PD-L1 blockade as useful for the treatment of the subject when there is the abnormality.