The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 10, 2020

Filed:

Sep. 14, 2018
Applicant:

Advanced Liquid Logic, Inc., San Diego, CA (US);

Inventors:

Vamsee K. Pamula, Cary, NC (US);

Michael G. Pollack, Durham, NC (US);

Ramakrishna Sista, Cary, NC (US);

Arjun Sudarsan, Carlsbad, CA (US);

Assignee:

ADVANCED LIQUID LOGIC, INC., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 15/06 (2006.01); G01N 33/00 (2006.01); G01N 33/48 (2006.01); G01N 35/00 (2006.01); G01N 1/00 (2006.01); G01N 1/10 (2006.01); B01L 3/00 (2006.01); G01N 33/543 (2006.01); B01F 13/00 (2006.01); B03C 1/02 (2006.01); B03C 1/28 (2006.01); B03C 1/30 (2006.01); B03C 5/00 (2006.01); C12N 15/10 (2006.01); G01N 33/561 (2006.01); B01F 11/00 (2006.01); B01L 7/00 (2006.01); G01N 35/10 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54333 (2013.01); B01F 11/0071 (2013.01); B01F 13/0071 (2013.01); B01F 13/0076 (2013.01); B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); B01L 3/502784 (2013.01); B01L 3/502792 (2013.01); B03C 1/02 (2013.01); B03C 1/288 (2013.01); B03C 1/30 (2013.01); B03C 5/005 (2013.01); C12N 15/1013 (2013.01); G01N 33/561 (2013.01); B01L 7/52 (2013.01); B01L 7/525 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0668 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/089 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0861 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/1827 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0406 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0421 (2013.01); B01L 2400/0424 (2013.01); B01L 2400/0427 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0442 (2013.01); B03C 2201/18 (2013.01); B03C 2201/26 (2013.01); G01N 2035/1046 (2013.01); Y10T 436/11 (2015.01); Y10T 436/25 (2015.01); Y10T 436/2575 (2015.01); Y10T 436/25625 (2015.01);
Abstract

Methods are provided for separating magnetically responsive beads from a droplet in a droplet actuator. Droplet operations electrodes and a magnet are arranged in a droplet actuator to manipulate a bead-containing droplet and position it relative to a magnetic field region that attracts the magnetically responsive beads. The droplet operations electrodes are operated to control the droplet shape and transport it away from the magnetic field region to form a concentration of beads in the droplet. The continued transport of the droplet away from the magnetic field causes the concentration of beads to break away from the droplet to yield a small, concentrated bead-containing droplet immobilized by the magnet.


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