The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Oct. 04, 2013
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Andrew J. Murphy, Croton-On-Hudson, NY (US);
George D. Yancopoulos, Yorktown Heights, NY (US);
Margaret Karow, Santa Rosa, CA (US);
Lynn Macdonald, White Plains, NY (US);
Sean Stevens, San Diego, CA (US);
Aris N. Economides, Tarrytown, NY (US);
David M. Valenzuela, Yorktown Heights, NY (US);
Rgeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.