The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Jun. 03, 2019
Applicant:
Cnpharm Co., Ltd., Seoul, KR;
Inventors:
Assignee:
CNPHARM CO., LTD., Seoul, KR;
Primary Examiner:
Int. Cl.
CPC ...
C08G 79/025 (2016.01); A61K 47/58 (2017.01); A61K 47/60 (2017.01); C08G 81/00 (2006.01); A61K 31/555 (2006.01); A61K 31/4745 (2006.01); A61K 31/337 (2006.01);
U.S. Cl.
CPC ...
C08G 79/025 (2013.01); A61K 31/337 (2013.01); A61K 31/4745 (2013.01); A61K 31/555 (2013.01); A61K 47/60 (2017.08); A61K 47/605 (2017.08); C08G 81/00 (2013.01);
Abstract
The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.