The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Nov. 29, 2017
Enanta Pharmaceuticals, Inc., Watertown, MA (US);
Guoqiang Wang, Belmont, MA (US);
Yong He, Lexington, MA (US);
Peng Dai, Auburndale, MA (US);
Guoyou Xu, Framingham, MA (US);
Bin Wang, Brighton, MA (US);
Jiang Long, Wayland, MA (US);
Yat Sun Or, Watertown, MA (US);
Enanta Pharmaceuticals, Inc., Watertown, MA (US);
Abstract
The present invention relates to processes for preparing a compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR or TGR5 modulators. Specifically, the present invention relates to bile acid derivatives and methods for their preparation and use. The present invention relates to a process for the preparation of a compound (II) and its salts and derivatives which are useful intermediates in the synthesis of biologically active molecules, especially in the synthesis of FXR and TGR5 modulators. The present invention also relates to a process for the preparation of a compound (III) and its diethylamine salt.