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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10584115 B1

PDFFull Text
Date of Patent:
Mar. 10, 2020

Filed:

Nov. 21, 2013

Substituted pyridine and pyrazine bmi-1 inhibitors

Applicant:

Ptc Therapeutics, Inc., South Plainfield, NJ (US);

Inventors:

Ramil Baiazitov, East Brunswick, NJ (US);

Soongyu Choi, Princeton, NJ (US);

Wu Du, Cranbury, NJ (US);

Seongwoo Hwang, Edison, NJ (US);

Chang-Sun Lee, Belle Mead, NJ (US);

Ronggang Liu, Berwyn, PA (US);

Young-Choon Moon, Belle Mead, NJ (US);

Steven D. Paget, Hillsborough, NJ (US);

Hongyu Ren, Dayton, NJ (US);

Nadiya Sydorenko, Princeton, NJ (US);

Richard Gerald Wilde, Somerville, NJ (US);

Assignee:

PTC THERAPEUTICS, INC., South Plainfield, NJ (US);

Attorney:

Hoffmann & Baron, LLP

Primary Examiner:

Yong L Chu

Int. Cl.
CPC ...
C07D 403/04 (2006.01); C07D 401/14 (2006.01); C07F 5/04 (2006.01); A61K 31/69 (2006.01); C07D 471/04 (2006.01); A61K 31/519 (2006.01); C07D 405/14 (2006.01); C07D 417/14 (2006.01); C07D 401/04 (2006.01); A61K 31/4985 (2006.01); C07D 413/04 (2006.01); C07D 403/14 (2006.01); A61K 45/06 (2006.01); C07D 487/04 (2006.01); A61K 31/497 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61K 31/497 (2013.01); A61K 31/4985 (2013.01); A61K 31/519 (2013.01); A61K 31/69 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/04 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 513/04 (2013.01); C07F 5/04 (2013.01);
Abstract

Amine substituted pyridine and pyrazine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

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