The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 10, 2020

Filed:

Feb. 06, 2017
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

Ravi Kapur, Sharon, MA (US);

Kyle C. Smith, Cambridge, MA (US);

Mehmet Toner, Charlestown, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 3/00 (2006.01); G01N 3/02 (2006.01); B01L 3/00 (2006.01); G01N 1/18 (2006.01); G01N 15/02 (2006.01); G01N 1/40 (2006.01); G01N 15/14 (2006.01); A61K 35/28 (2015.01); G01N 15/06 (2006.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); A61K 35/28 (2013.01); B01L 3/502715 (2013.01); B01L 3/502746 (2013.01); B01L 3/502753 (2013.01); G01N 1/4077 (2013.01); G01N 15/0255 (2013.01); G01N 15/0618 (2013.01); G01N 15/1484 (2013.01); B01L 3/502776 (2013.01); B01L 2200/0631 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0668 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/185 (2013.01); B01L 2400/043 (2013.01); B01L 2400/0409 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0436 (2013.01); B01L 2400/0457 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/082 (2013.01); G01N 2001/4088 (2013.01); G01N 2015/0053 (2013.01); G01N 2015/0065 (2013.01); G01N 2015/0288 (2013.01); G01N 2015/149 (2013.01); G01N 2015/1486 (2013.01); G01N 2015/1493 (2013.01);
Abstract

Extracting and concentrating particles from a first fluid sample includes: providing the first fluid sample to a fluid exchange module of a microfluidic device, providing a second fluid sample to the fluid exchange module, in which the first fluid sample and the second fluid sample are provided under conditions such that particle-free portions of the first fluid sample are shifted, and an inertial lift force causes the particles in the first fluid sample to cross streamlines and transfer into the second fluid sample; passing the second fluid sample containing the transferred particles to a particle concentration module under conditions such that particle-free portions of the second fluid sample are shifted, and such that the particles within the second fluid sample are focused to a streamline within the particle concentration module.


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