The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Sep. 19, 2017
Applicants:
Abt Holding Company, Cleveland, OH (US);
Regents of the University of Minnesota, Minneapolis, MN (US);
Inventors:
Catherine M. Verfaillie, Leuven, BE;
Uma Lakshmipathy, Carlsbad, CA (US);
Assignees:
ABT Holding Company, Cleveland, OH (US);
Regents of the University of Minnesota, Minneapolis, MN (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); A61K 48/00 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); C12N 15/1082 (2013.01);
Abstract
The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.