The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Oct. 09, 2015
Applicant:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Inventors:
Zheng-Yi Chen, Somerville, MA (US);
David Liu, Cambridge, MA (US);
Assignee:
Massachusetts Eye and Ear Infirmary, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/10 (2006.01); A61K 49/22 (2006.01); A61K 48/00 (2006.01); A61K 9/127 (2006.01); A61K 9/00 (2006.01); C12N 15/10 (2006.01); C12N 15/11 (2006.01); A61P 27/16 (2006.01); A61K 38/45 (2006.01); A61K 38/46 (2006.01); C12N 9/12 (2006.01); C12N 9/22 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0033 (2013.01); A61K 9/0046 (2013.01); A61K 9/127 (2013.01); A61K 38/45 (2013.01); A61K 38/465 (2013.01); A61K 48/0075 (2013.01); A61P 27/16 (2018.01); C12N 9/1241 (2013.01); C12N 9/22 (2013.01); C12N 15/102 (2013.01); C12N 15/11 (2013.01); C12N 15/111 (2013.01); C12Y 207/07 (2013.01); C12Y 301/00 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C12N 2310/14 (2013.01); C12N 2310/20 (2017.05); C12N 2320/32 (2013.01);
Abstract
A chimeric molecule of one or more proteins or peptides fused, complexed or linked to one or more anionic molecules. Efficient in vitro and in vivo delivery is attained by encapsulating these molecules in cationic lipids or cationic liposomes. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.