The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Sep. 17, 2018
Applicant:
Life Sciences Research Partners Vzw, Leuven, BE;
Inventor:
André Trouet, Leuven, BE;
Assignee:
COBIORES NV, Leuven, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/55 (2017.01); G01N 33/50 (2006.01); A61K 45/06 (2006.01); B82Y 5/00 (2011.01); A61K 47/65 (2017.01); A61K 47/60 (2017.01); A61K 47/66 (2017.01); A61K 31/337 (2006.01); A61K 31/395 (2006.01); A61K 31/4745 (2006.01); A61K 31/475 (2006.01); A61K 31/519 (2006.01); A61K 31/537 (2006.01); A61K 31/704 (2006.01); A61K 39/395 (2006.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
A61K 47/55 (2017.08); A61K 31/337 (2013.01); A61K 31/395 (2013.01); A61K 31/475 (2013.01); A61K 31/4745 (2013.01); A61K 31/519 (2013.01); A61K 31/537 (2013.01); A61K 31/704 (2013.01); A61K 39/395 (2013.01); A61K 45/06 (2013.01); A61K 47/54 (2017.08); A61K 47/60 (2017.08); A61K 47/65 (2017.08); A61K 47/67 (2017.08); B82Y 5/00 (2013.01); G01N 33/5011 (2013.01);
Abstract
The present invention relates to the field of oligopeptide prodrugs that are intended for the treatment of cancer. The selectivity of these prodrugs requires the presence of an (oligo)peptidic moiety and/or a protective capping group to ensure the prodrug stability in blood. It further in particular relates to the exemplary oligopeptidic moiety ALGP and to prodrugs comprising it. In particular it also relates to the capping group phosphonoacetyl and to prodrugs comprising this capping group.