The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 10, 2020

Filed:

Apr. 10, 2019
Applicant:

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Inventors:

Paul B. Yu, Boston, MA (US);

Jana Bagarova, Boston, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61K 45/06 (2006.01); C07D 405/14 (2006.01); C07D 401/12 (2006.01); C07D 487/04 (2006.01); C07D 491/056 (2006.01);
U.S. Cl.
CPC ...
A61K 31/517 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 487/04 (2013.01); C07D 491/056 (2013.01); A61K 2300/00 (2013.01);
Abstract

Provided herein are methods and compositions for the treatment and/or prevention of abnormal bone formation in a soft tissue. In certain embodiments, the methods and compositions treat and/or prevent a disease or disorder comprising abnormal bone formation in soft tissue. Exemplary diseases or disorders that can be treated with the methods and compositions described herein include, but are not limited to, heterotopic ossification diseases such as fibrodysplasia ossificans progressive, anklyosing spondylosis, traumatic heterotopic ossification, burn- or blast-injury associated heterotopic ossification, and joint replacement surgery associated heterotopic ossification.


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