The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Jun. 25, 2015
Applicant:
Ramot AT Tel-aviv University Ltd., Tel Aviv, IL;
Inventor:
Dan Peer, Kiryat Ono, IL;
Assignee:
RAMOT AT TEL-AVIV UNIVERSITY LTD., Tel Aviv, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); C12N 15/113 (2010.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1272 (2013.01); C12N 15/113 (2013.01); C12N 15/88 (2013.01); C12N 2310/14 (2013.01);
Abstract
There are provided liposomes, comprising cationic lipids, a membrane stabilizing lipid and at least one lipid conjugated to a polyethylene glycol (PEG) derivative, in particular PEG-amine, the liposomes are coated with a glycosaminoglycan, in particular, Hyaluronic Acid (HA), compositions comprising the same, methods for their preparation and uses thereof for the efficient delivery of nucleic acids, such as, si RNA molecules and for treating various conditions, such as cancer.