The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2020

Filed:

Sep. 20, 2017
Applicants:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Washington University, St. Louis, MO (US);

Inventors:

Daria Mochly-Rosen, Menlo Park, CA (US);

Gerald W. Dorn, II, Hamilton, OH (US);

Assignees:

Washington University, St. Louis, MO (US);

Stanford University, Stanford, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/08 (2006.01); C07K 14/705 (2006.01); G01N 33/50 (2006.01); C12N 9/14 (2006.01); G01N 33/547 (2006.01); G01N 33/566 (2006.01); G01N 33/58 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5079 (2013.01); C07K 7/08 (2013.01); C07K 14/705 (2013.01); C12N 9/14 (2013.01); C12Y 306/05 (2013.01); C12Y 310/01 (2013.01); G01N 33/547 (2013.01); G01N 33/566 (2013.01); G01N 33/582 (2013.01); A61K 38/00 (2013.01); C07K 2319/10 (2013.01); G01N 2500/00 (2013.01);
Abstract

Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.


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