The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2020

Filed:

Feb. 11, 2016
Applicant:

Loma Linda University, Loma Linda, CA (US);

Inventors:

Xiaolei Tang, Loma Linda, CA (US);

David J. Baylink, Redlands, CA (US);

K.-H. William Lau, Redlands, CA (US);

Michael Walter, Loma Linda, CA (US);

Assignee:

Loma Linda University, Loma Linda, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0784 (2010.01); C12N 9/02 (2006.01); A61K 38/44 (2006.01); A61K 35/15 (2015.01); A61K 48/00 (2006.01); C12P 19/34 (2006.01);
U.S. Cl.
CPC ...
C12Y 102/01036 (2013.01); A61K 35/15 (2013.01); A61K 38/44 (2013.01); A61K 48/00 (2013.01); C12N 9/0008 (2013.01); C12N 9/0073 (2013.01); C12P 19/34 (2013.01); C12Y 114/13013 (2013.01);
Abstract

Gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme. A method for treating one or more than one inflammation-related condition or disease, the method comprising administering gene-modified, lymphoid-tissue-homing dendritic cells that comprise a 1-alpha-hydroxylase gene and a retinaldehyde dehydrogenase 2 gene, where the 1-alpha-hydroxylase gene is expressed to produce functional 1-alpha-hydroxylase enzyme and the retinaldehyde dehydrogenase 2 gene is expressed to produce functional retinaldehyde dehydrogenase 2 gene enzyme.


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