The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2020
Filed:
Oct. 15, 2018
University of Rochester, Rochester, NY (US);
John L. Daiss, Rochester, NY (US);
Edward Schwarz, Rochester, NY (US);
John J. Varrone, Rochester, NY (US);
James Brodell, Rochester, NY (US);
Sheila Bello-Irizarry, Rochester, NY (US);
University of Rochester, Rochester, NY (US);
Abstract
Disclosed herein are monoclonal antibodies or binding portion thereof that bind specifically to aspp. autolysin N-acetylmuramoyl-L-alanine amidase catalytic domain and/or cell wall binding domain, as well as pharmaceutical compositions containing the same. Cell lines expressing the monoclonal antibodies, including hybridomas, are also disclosed. Methods of using the monoclonal antibodies for installation of orthopedic implants, grafts or medical devices, treating or preventing ainfection, and treating osteomyelitis are described, as are diagnostic methods for the detection ofin a sample.