logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10577408 B1

PDFFull Text
Date of Patent:
Mar. 03, 2020

Filed:

Aug. 11, 2017

Transduced t cells expressing human sstr2 and application thereof

Applicant:

Cornell University, Ithaca, NY (US);

Inventor:

Moonsoo Jin, New York, NY (US);

Assignee:

Cornell University, Ithaca, NY (US);

Attorneys:

Perkins Coie LLP

Viola T. Kung

Primary Examiner:

Valarie E Bertoglio

Int. Cl.
CPC ...
C07K 16/00 (2006.01); C12P 21/08 (2006.01); C07K 14/72 (2006.01); A61K 38/17 (2006.01); A61K 51/08 (2006.01); A61K 39/00 (2006.01); A61K 35/17 (2015.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 14/723 (2013.01); A61K 35/17 (2013.01); A61K 38/1796 (2013.01); A61K 39/0011 (2013.01); A61K 51/083 (2013.01); A61K 51/088 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/70553 (2013.01); C12N 5/0636 (2013.01); A61K 2039/515 (2013.01); A61K 2039/54 (2013.01); C07K 2319/03 (2013.01); C07K 2319/74 (2013.01); C12N 2510/00 (2013.01);
Abstract

The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT imaging sensitivity. The present invention is also directed to transduced T cells expressing SSTR2 and chimeric antigen receptor (CAR). In one embodiment, the CAR is specific to human ICAM-1 and the CAR comprises a binding domain that is scFv of anti-human ICAM-1, or an I domain of the αL subunit of human lymphocyte function-associated antigen-1. In another embodiment, the CAR is specific to human CD19, and the CAR comprises a binding domain that is scFv of anti-human CD19. The present invention is further directed to using the above transduced T cells for monitoring T cell distribution in a patient by PET/CT imaging and/or treating cancer.

Find Patent Forward Citations

Loading…