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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10577394 B1

PDFFull Text
Date of Patent:
Mar. 03, 2020

Filed:

Jun. 12, 2015

Ganirelix precursor and method for preparing ganirelix acetate by using the same

Applicant:

Hybio Pharmaceutical Co., Ltd., Shenzhen, CN;

Inventors:

Youjin Chen, Shenzhen, CN;

Jian Liu, Shenzhen, CN;

Yaping Ma, Shenzhen, CN;

Jiancheng Yuan, Shenzhen, CN;

Assignee:

HYBIO PHARMACEUTICAL CO., LTD., Shenzhen, Guangdong, CN;

Attorney:

Ladas & Parry, LLP

Primary Examiner:

James H Alstrum-Acevedo

Assistant Examiner:

Tara L Martinez

Int. Cl.
CPC ...
C07K 7/23 (2006.01); C07K 1/107 (2006.01); C07K 1/06 (2006.01); C07K 1/04 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
C07K 7/23 (2013.01); C07K 1/04 (2013.01); C07K 1/06 (2013.01); C07K 1/107 (2013.01); C07K 7/06 (2013.01); Y02P 20/55 (2015.11);
Abstract

Disclosed is a method for preparing ganirelix acetate. The method includes the following steps: respectively replacing Fmoc-HArg(Et)-OH and Fmoc-D-HArg(Et)-OH by employing Fmoc-Lys(Boc)-OH and Fmoc-D-Lys(Boc)-OH or Fmoc-Lys(Alloc)-OH and Fmoc-D-Lys(Alloc)-OH; synthesizing a ganirelix precursor I or ganirelix precursor II-peptide resin in advance; and then respectively performing modifications and treatments on side chain amino groups of Lys and D-Lys in the precursor I or the precursor II-peptide resin to obtain ganirelix acetate. The ganirelix acetate synthesized therefrom is high in purity, has few impurities and a relatively low cost, and is suitable for large-scale production.

Find Patent Forward Citations

Chen, Youjin. (2020). Ganirelix precursor and method for preparing ganirelix acetate by using the same (U.S. Patent No. 10577394). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10577394

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