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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10577371 B1

PDFFull Text
Date of Patent:
Mar. 03, 2020

Filed:

Sep. 18, 2018

Small molecule histone methyltransferase suv39h1 inhibitor and uses thereof

Applicants:

Augusta University Research Institute, Inc., Augusta, GA (US);

Department of Veterans Affairs, Washington, DC (US);

Inventors:

Chunwan Lu, Augusta, GA (US);

Iryna Lebedyeva, Augusta, GA (US);

Kebin Liu, Augusta, GA (US);

Assignees:

Augusta University Research Institute, Inc., Augusta, GA (US);

Department of Veterans Affairs, Washington, DC (US);

Attorney:

Smith, Gambrell & Russell, LLP

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 39/395 (2006.01); A61K 31/407 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/407 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); C07K 2317/76 (2013.01);
Abstract

Compositions for the inhibition of SUV39H1 methyltransferase activity and methods of use thereof are provided. The disclosed compositions may be used for treating certain types of cancer, inducing apoptosis in a cancer cell, increasing cell sensitivity to FasL-induced apoptosis, and overcoming cancer cell resistance to apoptosis and/or certain types of cancer immunotherapy.

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Lu, Chunwan. (2020). Small molecule histone methyltransferase suv39h1 inhibitor and uses thereof (U.S. Patent No. 10577371). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10577371

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