The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2020

Filed:

Mar. 24, 2016
Applicants:

The Florey Institute of Neuroscience and Mental Health, Melbourne, AU;

The University of Melbourne, Victoria, AU;

Inventors:

Spencer John Williams, Coburg, AU;

Bevyn Jarrott, Mount Martha, AU;

Assignees:

The Florey Institute, Melbourne, AU;

The University of Melbourne, Victoria, AU;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/36 (2006.01); C07C 217/18 (2006.01); C07D 231/56 (2006.01); C07D 239/26 (2006.01); C07D 403/12 (2006.01); C07D 401/14 (2006.01); C07D 271/06 (2006.01); C07C 255/58 (2006.01); C07C 217/58 (2006.01); C07C 233/43 (2006.01); C07C 311/37 (2006.01); C07C 311/16 (2006.01);
U.S. Cl.
CPC ...
C07C 217/18 (2013.01); C07C 217/58 (2013.01); C07C 233/43 (2013.01); C07C 255/58 (2013.01); C07C 311/16 (2013.01); C07C 311/37 (2013.01); C07D 213/36 (2013.01); C07D 231/56 (2013.01); C07D 239/26 (2013.01); C07D 271/06 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01);
Abstract

The present disclosure relates generally to compounds having activity as voltage-gated sodium channel blockers and their use in the field of therapeutic treatment, including the therapy or management of conditions associated with excessive, unwanted, inadequate or otherwise undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In some embodiments, the disclosure relates to aryloxy-substituted amines for use as sodium channel blockers or modulators. Methods for their manufacture and compositions containing the compounds are also disclosed.


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