The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2020

Filed:

Dec. 06, 2013
Applicants:

Onconova Therapeutics, Inc., Newtown, NJ (US);

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Manoj Maniar, Fremont, CA (US);

Azra Raza, New York, NY (US);

Francois Wilhelm, Princeton, NJ (US);

Inventors:

Manoj Maniar, Fremont, CA (US);

Azra Raza, New York, NY (US);

Francois Wilhelm, Princeton, NJ (US);

Assignee:

ONCONOVA THERAPEUTICS, INC., Newtown, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/198 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); A61K 31/706 (2006.01); A61K 31/454 (2006.01); A61K 31/428 (2006.01); A61K 31/10 (2006.01);
U.S. Cl.
CPC ...
A61K 31/198 (2013.01); A61K 31/10 (2013.01); A61K 31/428 (2013.01); A61K 31/454 (2013.01); A61K 31/706 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01);
Abstract

The invention discloses a method of treating cancer refractory to an anticancer agent comprising administering to a cancer patient a pharmaceutical composition comprising at least one compound of Formula 1 Where Ris selected from the group consisting of —NH, —NH—CH—COOH, —NH—CH(CH)—COOH, —NH—C(CH)—COOH, —NH—CH—CH—OH and —N—(CHCHOH)or a pharmaceutically acceptable salt of such a compound, and an anticancer agent.


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