The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 25, 2020

Filed:

Apr. 20, 2016
Applicants:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Colgate-palmolive Company, New York, NY (US);

Inventors:

Alexander Rickard, Ann Arbor, MI (US);

Adam Underwood, Cheektowaga, NY (US);

Laurence Du-Thumm, Princeton, NJ (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/74 (2006.01); G01N 33/68 (2006.01); A61K 31/198 (2006.01); A61K 31/4425 (2006.01); A61K 9/00 (2006.01); A61Q 11/00 (2006.01); G01N 33/84 (2006.01);
U.S. Cl.
CPC ...
C12N 15/746 (2013.01); A61K 9/0053 (2013.01); A61K 31/198 (2013.01); A61K 31/4425 (2013.01); G01N 33/6812 (2013.01); G01N 33/84 (2013.01); G01N 2500/10 (2013.01);
Abstract

The present disclosure relates to compositions and methods for destabilizing biofilms, altering biofilm 3D structure, and dispersing biofilms, in order to enhance biofilm cell removal and/or sensitivity to other agents (e.g., environmental or co-applied treatments). In particular, the present disclosure relates to the use of L-arginine in the removal and/or sensitization (e.g., to antimicrobials) of microorganisms in medical, industrial, domestic, or environmental applications, as well as treatment of bacterial infections (e.g., in biofilms).


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