The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2020
Filed:
Feb. 28, 2013
Applicant:
Sigma-aldrich Co. Llc, St. Louis, MO (US);
Inventors:
Qingzhou Ji, St. Louis, MO (US);
Carol Kreader, St. Louis, MO (US);
Assignee:
Sigma-Aldrich Co. LLC, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/10 (2006.01); C07K 14/47 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1029 (2013.01); C07K 14/47 (2013.01); C12Y 203/01048 (2013.01); C07K 2319/09 (2013.01); C07K 2319/81 (2013.01);
Abstract
The present disclosure provides compositions and methods for acetylating histones at targeted chromosomal locations in a cell. In particular, the disclosure provides a fusion protein comprising a DNA binding domain and at least one histone acetyltransferase (HAT) domain, such that the DNA binding domain targets the fusion protein to a targeted chromosomal location and the HAT domain acetylates histones at the targeted location.