The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2020
Filed:
Jan. 09, 2017
Applicant:
Replimune Limited, Oxford, GB;
Inventor:
Robert Coffin, Oxford, GB;
Assignee:
Replimune Limited, Oxford, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 7/00 (2006.01); A61P 35/00 (2006.01); A61K 35/763 (2015.01); A61K 45/06 (2006.01); C07K 14/005 (2006.01); C07K 14/535 (2006.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); A61K 35/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 35/763 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/005 (2013.01); C07K 14/535 (2013.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); C12N 2710/16621 (2013.01); C12N 2710/16622 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16633 (2013.01); C12N 2710/16643 (2013.01); C12N 2740/13022 (2013.01);
Abstract
The present invention relates to an oncolytic virus which is, or is derived from, a clinical isolate which has been selected by comparing the abilities of a panel of three or more clinical isolates of the same viral species to kill tumor cells of two or more tumor cell lines in vitro and selecting a clinical isolate which is capable of killing cells of two or more tumor cell lines more rapidly and/or at a lower dose in vitro than one or more of the other clinical isolates in the panel.