The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2020
Filed:
Mar. 26, 2018
Eutilex Co., Ltd., Seoul, KR;
Byoung S. Kwon, Gwangmyeong-si, KR;
Hyun-Guy Kang, Seoul, KR;
Kwang-Hui Kim, Gyeonggi-do, KR;
Young-Woo Kim, Gyeonggi-do, KR;
Young Ho Kim, Goyang-si, KR;
Byung-Kiu Park, Seoul, KR;
Sang-Yoon Park, Seoul, KR;
Sang-Jae Park, Gyeonggi-do, KR;
Hyeon-Seok Eom, Seoul, KR;
Ho-Sik Oh, Goyang-si, KR;
Heon Yoo, Seoul, KR;
Don-Gil Lee, Gyeonggi-do, KR;
Seung-Hoon Lee, Seoul, KR;
Young-Joo Lee, Seoul, KR;
Jin-Soo Lee, Gyeonggi-do, KR;
Beom-Kyu Choi, Gyeonggi-do, KR;
Eutilex Co., Ltd., Seoul, KR;
Abstract
Provided is a method for isolating and proliferating autologous cancer antigen-specific CD8T cells, and more particularly, a method for selecting an epitope recognized by CD8T cells from autologous cancer antigens present in blood of individual cancer patients; and isolating autologous cancer antigen-specific CD8T cells by using a peptide of the selected epitope, and a method of massively proliferating CD8T cells by using the method. According to the present invention, it is possible to isolate autologous cancer antigen-specific CD8T cells by using the peptide of the CD8 T cell epitope of the autologous cancer antigen present in blood of individual cancer patients instead of a heterologous antigen. Therefore, by using T cells recognizing the autologous cancer antigen, it is possible to effectively select and eliminate cancer cells derived from the cancer patient's own cells. Thus, T cells can be applied to treatment and alleviation of cancer diseases without side effects.