The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 25, 2020

Filed:

Oct. 30, 2017
Applicant:

Universitat Stuttgart, Stuttgart, DE;

Inventors:

Klaus Pfizenmaier, Tiefenbronn, DE;

Roland Kontermann, Nurtingen, DE;

Martin Siegemund, Stuttgart, DE;

Assignee:

UNIVERSITAT STUTTGART, Stuttgart, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/525 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C07K 19/00 (2006.01); A61K 38/19 (2006.01); A61K 39/395 (2006.01); C07K 14/705 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); A61K 38/191 (2013.01); A61K 39/3955 (2013.01); C07K 14/525 (2013.01); C07K 14/70575 (2013.01); C07K 16/28 (2013.01); C07K 19/00 (2013.01); A61K 39/001102 (2018.08); A61K 2039/505 (2013.01); C07K 16/30 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/31 (2013.01); C07K 2319/33 (2013.01); C07K 2319/43 (2013.01); C07K 2319/74 (2013.01);
Abstract

The present invention relates in general to the field of TNF ligand family members. In more detail the present invention relates to polypeptides comprising at least three components A, each of which comprises the sequence of a TNF homology domain (THD) of a TNF ligand family member, or a functional derivative thereof, and comprising at least one component B consisting of a Vregion and a Vregion linked directly to each other with a linker sequence L which has a length of <12 amino acids. Furthermore, the present invention also relates to nucleic acids encoding such polypeptides and pharmaceutical compositions thereof.


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