The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 25, 2020

Filed:

Jul. 31, 2013
Applicant:

University of the West Indies, Kingston, JM;

Inventors:

Trevor Herbert Yee, Kingston, JM;

Helen Marjorie Jacobs, Kingston, JM;

Assignee:

University of The West Indies, St. Augustine, TT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 36/00 (2006.01); C07D 311/78 (2006.01); A61K 36/185 (2006.01); A61K 31/352 (2006.01); C07D 311/94 (2006.01);
U.S. Cl.
CPC ...
C07D 311/78 (2013.01); A61K 31/352 (2013.01); A61K 36/185 (2013.01); C07D 311/94 (2013.01); A61K 2236/331 (2013.01); A61K 2236/39 (2013.01);
Abstract

Improved processes for the extraction of quassinoids such as quassin and neoquassin from natural substances containing these compounds are described. The process uses compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration. In a first embodiment, the process includes a sonication method using water and no organic solvent. The process is highly efficient and comprises fewer steps than other processes known in the art. In a second embodiment, a method of extracting quassinoids from natural substance comprising bark of a plant of the plant family Simaroubaceae is also disclosed. In a third embodiment, indirect sonication of quassinoids is described using a mixture of polar and non-polar organic solvents.


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