IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10570090 B1

PDFFull Text
Date of Patent:
Feb. 25, 2020

Filed:

Jun. 05, 2017

Substituted 6,7-dihydro-5h-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof

Applicant:

Sanofi, Paris, FR;

Inventors:

Monsif Bouaboula, Paris, FR;

Maurice Brollo, Paris, FR;

Victor Certal, Paris, FR;

Youssef El-Ahmad, Paris, FR;

Bruno Filoche-Romme, Paris, FR;

Frank Halley, Paris, FR;

Gary McCort, Paris, FR;

Laurent Schio, Paris, FR;

Michel Tabart, Paris, FR;

Corinne Terrier, Paris, FR;

Fabienne Thompson, Paris, FR;

Assignee:

SANOFI, Paris, FR;

Attorney:

Kelly L. Bender

Primary Examiner:

Matthew P Coughlin

Assistant Examiner:

Sagar Patel

Int. Cl.
CPC ...
A61K 31/40 (2006.01); A61K 31/025 (2006.01); C07C 13/32 (2006.01); C07C 22/08 (2006.01); C07D 207/12 (2006.01); C07D 403/12 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07F 7/08 (2006.01); C07D 417/12 (2006.01); C07F 5/02 (2006.01);
U.S. Cl.
CPC ...
C07D 207/12 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07F 5/025 (2013.01); C07F 7/0812 (2013.01);
Abstract

Compounds of formula (I): wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a —COOH, a —OH or a —OPO(OH)group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a —OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a —COOH, —OH or —OPO(OH)group, then R5 represents a hydrogen atom; when R5 represents a —OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl and heterocycloalkyl group;and the preparation and the therapeutic uses of the compounds of formula (I) as inhibitors and degraders of estrogen receptors, useful especially in the treatment of cancer.

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