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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10568992 B1

PDFFull Text
Date of Patent:
Feb. 25, 2020

Filed:

Apr. 14, 2016

Peptides for supporting endothelial progenitor cell rolling and capture and endothelialization of biomaterials

Applicant:

Auburn University, Auburn, AL (US);

Inventors:

Elizabeth A. Lipke, Auburn, AL (US);

Wen Jun Seeto, Auburn, AL (US);

Assignee:

Auburn University, Auburn, AL (US);

Attorney:

Meunier Carlin & Curfman LLC

Primary Examiner:

Karlheinz R Skowronek

Assistant Examiner:

Li N Komatsu

Int. Cl.
CPC ...
A61L 31/16 (2006.01); C12N 5/071 (2010.01); A61L 31/04 (2006.01); A61K 38/08 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 31/00 (2006.01);
U.S. Cl.
CPC ...
A61L 31/16 (2013.01); A61L 27/227 (2013.01); A61L 27/3683 (2013.01); A61L 31/005 (2013.01); A61L 31/047 (2013.01); C12N 5/069 (2013.01); C12N 2533/30 (2013.01); C12N 2533/50 (2013.01);
Abstract

The present invention relates to the production of endothelialized matrices and materials from immature endothelial cells using substrates to which particular peptides have been grafted. The resultant substrates can be used to capture and support immature endothelial cells. Further, the methods and compositions of the present invention provide viable cell delivery platforms that allow for production and provision of endothelialized medical devices and implants, including vascular grafts, stents, shunts, and valves, endothelialized surfaces and channels for in vitro testing devices, including microfluidic chips, and materials that support vascularization such as for use in engineered tissues. The present invention includes novel methods required for the successful production of cellularized substrates, systems and components used for the same, and methods of using the resultant cell and tissue compositions.

Find Patent Forward Citations

Lipke, Elizabeth. (2020). Peptides for supporting endothelial progenitor cell rolling and capture and endothelialization of biomaterials (U.S. Patent No. 10568992). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10568992

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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