The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2020
Filed:
Sep. 05, 2017
New York University, New York, NY (US);
Molsoft Llc, San Diego, CA (US);
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Maxim Totrov, San Diego, CA (US);
Xunqing Jiang, Brooklyn, NY (US);
Ruimin Pan, New York, NY (US);
Susan Zolla-Pazner, New York, NY (US);
Xiangpeng Kong, New York, NY (US);
New York University, New York, NY (US);
Molsoft LLC, San Diego, CA (US);
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Abstract
The present invention relates to isolated immunogenic polypeptides and their use. In one aspect, the isolated immunogenic polypeptide includes a scaffold polypeptide having a hairpin loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond. The scaffold polypeptide directs self-assembly with two other of the scaffold polypeptides to form a trimeric structure, which constrains the one or more epitopes to a conformation that is (i) substantially similar to one or more native pathogen epitopes in trimeric conformation and (ii) capable of binding an antibody reactive to the one or more native pathogen epitopes in trimeric conformation. Another aspect relates to an isolated immunogenic polypeptide that includes a scaffold polypeptide having a native loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond. The scaffold polypeptide directs self-assembly with four other of said scaffold polypeptides to form a pentameric structure, which constrains the one or more epitopes to a conformation capable of binding an antibody reactive to one or more native pathogen epitopes.