The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2020
Filed:
Aug. 28, 2009
Pia Dosenovic, Stockholm, SE;
Gunilla Karlsson Hedestam, Stockholm, SE;
Richard Wyatt, La Jolla, CA (US);
Staffan Paulie, Nacka Strand, SE;
Pia Dosenovic, Stockholm, SE;
Gunilla Karlsson Hedestam, Stockholm, SE;
Richard Wyatt, La Jolla, CA (US);
Staffan Paulie, Nacka Strand, SE;
MABTECH AB, Nacka Strand, SE;
Abstract
An improved assay is described where a surface is provided with immobilized anti-Ig antibodies rather than antigen and where specific antibody-secreting cells (ASC) are detected using soluble antigen probes containing one of several possible labels. The method gives improved sensitivity with less background and is also more representative because antigen binding does not employ immobilized antigen. The assay is particularly effective for measuring antibody secreting cells against HIV, for determining whether an infection is acute as opposed to old or latent, for mapping epitopes and for measuring for ASCs against different antigens in the same reaction.