The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2020
Filed:
Dec. 02, 2015
Anaeropharma Science, Inc., Tokyo, JP;
Koichi Koseki, Tokyo, JP;
Koichiro Shioya, Tokyo, JP;
Satoshi Kobayashi, Nagano, JP;
Yuko Shimatani, Nagano, JP;
Takeshi Masaki, Nagano, JP;
Hitomi Shimizu, Nagano, JP;
Tomio Matsumura, Nagano, JP;
Masami Okabe, Tokyo, JP;
Kengo Inoue, Tokyo, JP;
Anaeropharma Science, Inc., Tokyo, JP;
Abstract
The object of the invention is to provide an anaerobic enterobacterium having a higher therapeutic effect on an anaerobic site such as a solid tumor tissue and an ischemic disease site. A bacterium of the genus, which is transformed with a plasmid co-expressing two types of heterologous polypeptides and comprising two types of secretory expression cassettes each sequentially comprising a promoter DNA functioning in the bacterium of the genus; a DNA encoding a secretory signal peptide; a DNA encoding a heterologous polypeptide; and a terminator DNA functioning in the bacterium of the genus, efficiently secretes the two types of heterologous peptides, i.e., two types of antibodies having anticancer effects, outside the bacterial cell.